HLA-DPB1 as an Independent Predictor of Non-Relapse Mortality at Identical Match Scores: Evidence for a Primary Unscored Information Channel in Unrelated Donor Selection
HLA-DPB1 as an Independent Predictor of Non-Relapse Mortality at Identical Match Scores: Evidence for a Primary Unscored Information Channel in Unrelated Donor Selection
Power law analysis of outcome variance within HLA match score groups across N=35,471 transplant pairs. Within-group overdispersion is 6-9x binomial expectation at every match level. At identical 9/10 match scores, PBM immunopeptidome divergence produces a 6.8 percentage point difference in 3-year overall survival. HLA-DPB1 carries HR_NRM = 1.50 and is not in the standard 10/10 cascade. Patient age asymmetry carries HR = 1.78 at identical match scores. Three actionable protocol recommendations: add HLA-DPB1 to the cascade, formalize age asymmetry scoring, adopt immunopeptidome divergence as tiebreaker.
HLA-DPB1, unrelated donor transplant, non-relapse mortality, power law, within-group variance, immunopeptidome, PTCy, transplant immunology, HLA Matching, donor selection
HLA-DPB1, unrelated donor transplant, non-relapse mortality, power law, within-group variance, immunopeptidome, PTCy, transplant immunology, HLA Matching, donor selection
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).0 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Average influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Average
Citations provided by BIP!Popularity provided by BIP!