Sluder’s syndrome, also known as sphenopalatine neuralgia, is a rare neurological disorder associated with irritation or inflammation of the sphenopalatine ganglion. The condition is characterized by severe unilateral facial pain accompanied by autonomic symptoms such as nasal congestion, lacrimation, and rhinorrhea. Due to its similarity to other facial pain syndromes, Sluder’s syndrome is often misdiagnosed. This article reviews the etiology, pathogenesis, clinical manifestations, diagnostic approaches, and treatment methods of Sluder’s syndrome. Early diagnosis and appropriate management are essential for improving patients’ quality of life.