This document establishes the data governance framework for the Genome EDIC Secondary Use Framework, defining the rights and responsibilities of all actors throughout the data lifecycle for secondary use of genomic and health data. The framework identifies and delineates roles for key actors including the Genome EDIC governance structure (Assembly of Members, Central Coordination, and 1+MG Data Access Committee), data providers, 1+MG Data Holders, national DACs, IT infrastructure providers, National Coordination Points (1+MG NCP), and users with their hosting organisations. All recommendations have been consolidated into a comprehensive table designed to provide clarity on each actor's responsibilities within the framework. The governance model is built on two fundamental principles: data sovereignty (data remain in countries) and national responsibility (governments ensure necessary structures are in place). The framework balances national implementation flexibility with harmonisation requirements, particularly ensuring a homogeneous user experience across Member States. Clear distinction is made between the Genome EDIC's governing level (Assembly of Members setting principles and minimum requirements) and operational level (Central Coordination acting as one-stop-shop and ensuring quality adherence). Member States bear responsibility for establishing the required competencies in genomic and health data management, secure IT infrastructure operations, and appropriate tools for data subject interaction. The Genome EDIC Central Coordination will streamline operations by handling tasks more efficiently at the central level, avoiding duplication of efforts across countries. The framework is designed for integration with the European Health Data Space, with detailed recommendations and an overview table provided to support targeted implementation by stakeholders.