Background: Gout in modern science is a metabolic disorder of purine metabolism which can be diagnosed by elevated serum uric acid. The symptomatology of Vatarakta like Shool, Shoth, Sparshagyatwam etc. mimics the symptoms of gout. It is a form of inflammatory arthritis characterized by recurrent attacks of red, tender, hot and swollen joint caused by deposition of needle like crystal of uric acid known as monosodium Urate crystals. In Classics, it is mentioned that Ksheer Siddha Basti is considered best for Vatarakta as Ksheer pacifies Dushit Rakta and Basti procedure itself pacifies Vata. Aim: To evaluate the efficacy of Kala Basti with Madhuyashtyadi Niruha Basti and Balaguduchyadi Anuvasana Basti in the management of Vatarakta w.s.r to Gout. Materials and Methods: This is Open label randomized single arm prospective interventional Clinical Trial. A total of 30 patients were treated by giving Kala Basti with Madhuyashtyadi Niruha Basti and Balaguduchyadi Anuvasana Basti. The observations were recorded using an ordinal scale (grading method), the Wilcoxon Signed Rank Test was applied to evaluate the effect of Madhuyashtyadi Basti before treatment (BT) and after treatment (AT). Results: The results presented indicate that all seven subjective parameters—Sandhishoola, Sandhishotha, Kshate Atiruk, Twak Vaivarnaya, Daha, Sparsha Agyatavyam, and Stabdhata—showed a statistically significant reduction after treatment. Conclusion: Madhuyashtyadi Niruha and Balaguduchyadi Anuvasana Basti in Kala Basti Krama is found to be effective in Vatarakta i.e Gout.