Skin is the largest organ of the human body and serves as the primary interface between the internal and external environment. In Ayurveda, skin is described as Twacha, an Upadhatu of Mamsa Dhatu, formed during embryogenesis and composed of multiple layers, each with specific structural and functional significance. Modern science explains skin as a complex organ consisting of epidermis, dermis and hypodermis with well-defined histological layers.This article attempts a comparative and integrative review of the structural anatomy of skin as described in Ayurvedic classical texts and modern anatomy, highlighting similarities, differences and clinical relevance.