Abstract Background: Laparoscopic Totally Extraperitoneal (TEP) repair has become a preferred technique for inguinal hernia repair due to reduced postoperative pain, early recovery, and low recurrence rates. Conventional mesh fixation methods may contribute to postoperative neuralgia. Self-retaining meshes such as Progrip™ eliminate the need for fation and may improve outcomes.Objectives: To evaluate postoperative outcomes, particularly recurrence and chronic groin pain, in patients undergoing laparoscopic TEP inguinal hernia repair using self-retaining mesh. Methods: This prospective observational study included 2,544 patients undergoing TEP inguinal hernia repair between June 2016 and June 2024. Patients with uncomplicated inguinal hernias were included. Operative details, postoperative recovery, complications, chronic pain, and recurrence were assessed during follow-up ranging from 70 days to 8 years. Results: The majority of patients were male, with a male-to-female ratio of 20:1 and age range of 45–65 years. Unilateral hernias were present in 821 patients and bilateral in 191. Primary hernias accounted for 2,041 cases, while 504 were recurrent. Mean operative time ranged from 25–45 minutes for unilateral repairs and 40–55 minutes for bilateral repairs. No intraoperative complications or conversions occurred. Hospital stay averaged 3–4 days, and most patients resumed normal activity within one week. Early postoperative complications occurred in three patients. Chronic pain beyond three months was not observed. Only one recurrence was noted during follow-up. No mesh-related complications were reported. Conclusion: Laparoscopic TEP repair using self-retaining mesh is a safe and effective technique associated with minimal postoperative morbidity, negligible chronic pain, and extremely low recurrence rates.