Abstract We propose a theoretical framework suggesting that cancer may be productively understood as a lattice degradation phenomenon within the water-matrix lattice (Holmes, 2025), and that this understanding may open previously unconsidered intervention pathways warranting investigation by qualified researchers across multiple fields. Cancer cells exhibit consistently low electrical potential (10–20 mV) compared to healthy cells (80–100 mV), an observation documented since Cone (1970s) and extended by Pollack (2024) through the exclusion zone (EZ) water framework. We connect this voltage deficit to the water-matrix lattice described by Holmes (2025), in which the asymmetric hydrogen bonding rule — one strong bond and one weak bond per molecule, invariant across all phases — constitutes the structural fabric of the cellular environment. We suggest that locally induced negative effective gravitational coupling — experimentally demonstrated by Hu et al. (2013) in water at frequencies between 4.1 Hz and 4.85 Hz using resonator arrays — may warrant investigation as a potential mechanism for selective detachment of weakly coupled cancerous tissue from strongly coupled healthy tissue. We further suggest that the intact hydrogen bond network surrounding a tumor may provide a thermodynamically favorable extraction pathway warranting study. These ideas connect five previously isolated lines of published evidence: EZ water biophysics, bioelectric oncology, analog gravity experiments in water, frequency-selective cancer cell disruption, and the water-matrix lattice hypothesis. The connections are offered not as proven conclusions but as a research architecture — a map of possibilities for qualified professionals.