Setaria italica (L.) is an annual herbaceous plant that is commonly known as Foxtail millet. It is regularly consumed by humans and animals, and rural peoples have traditionally used it for treating inflammation. This review focusses on antibacterial activity of Setaria italica husk. This study demonstrated that phenolic acids, coumarins, carotenoids and flavonoids are the major antibacterial components found in this plant. These phytochemicals exhibit antibacterial activity through various mechanisms, including disruption of bacterial cell membranes, inhibition of nucleic acid and protein synthesis, interference with metabolic pathways and alteration of intracellular ph. According to this study phenolic acids shows strong antibacterial activity against both gram-positive and gram-negative bacteria. This plant produces some of the pharmacological activity such as anti-cancer, hepatoprotective, appetite stimulant, anti-lipase, anti-inflammatory, anti-fungal, anti-hyperlipidemic, anti-hypertensive, anti-diabetic, anti-oxidant, anti-bacterial, trypsin inhibition, cytotoxic and hypoglycemic activity. There are 2 extraction techniques commonly used to extract the phytochemicals. They are conventional and non- conventional methods. Sonicator is a device used to extract the bioactive compounds from the plant material.