Abstract This research presents an interdisciplinary analysis of how fundamental constants govern the physical world across different scales.The first part of the work focuses on the role of Phi (the Golden Ratio) in biology, specifically its presence in the helical geometry of DNA and RNA molecules, as well as the structural and energetic efficiency of ATP.The second part investigates the chemical organization of the Mendeleev Periodic Table, establishing a mathematical connection between the distribution of elements and the general properties of salts, bases, and acids.Finally, the study examines the application of Pi in modeling geological catastrophes, exploring how this constant describes the dynamics of natural disasters and systemic collapses. The provided materials offer a unified perspective on the mathematical patterns that link molecular biology, chemical systems, and large-scale geological processes.