
Rabies is a universally fatal zoonotic disease once clinical signs appear, yet it is entirely preventable through timely vaccination and post-exposure prophylaxis. Modern cell-culture rabies vaccines have demonstrated high efficacy and safety over several decades. Recent international alerts regarding the circulation of falsified rabies vaccine batches have generated concern and have been widely reported as “rabies vaccine failure.” This article critically examines the concept of rabies vaccine failure, differentiating true biological failure from pharmaceutical quality and supply-chain failures. In addition, current rabies vaccine production technologies, manufacturing processes, and quality control measures are reviewed. The implications of counterfeit vaccines for clinical practice, public trust, and regulatory systems are discussed. Evidence indicates that recent events reflect failures of product integrity rather than intrinsic limitations of rabies vaccine technology.
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