Synthetic lethal relationship between Ezh2 and Parp1 in cancer cells.
Mamoor, Shahan;
Synthetic lethal relationship between Ezh2 and Parp1 in cancer cells.
By measuring cell death following loss of gene function using whole transcriptome technologies we observed a strong, synthetic lethal relationship between the Poly (ADP-ribose) polymerase Parp1 and the H3K27 methyltransferase Ezh2. Parp1 chemotherapeutic regimens may benefit from adjunctive Ezh2 inhibition.
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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Cancer Research
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