This study explores the use of nanofertilizers in agroecosystems to enhance soil fertility and crop yields among smallholder women farmers in Malawi. A mixed-method approach including surveys, interviews, and soil sample analysis was employed to evaluate the efficacy and sustainability of these systems over multiple years. Nanofertilizers showed an average increase in crop yields by 15% compared to conventional fertilizers, with statistically significant confidence interval (CI) [9.2%, 20.8%] at a 95% level. The inclusion of women farmers in nanofertilizer adoption significantly improved their economic conditions and environmental sustainability in Malawi's agricultural landscapes. Policy makers should incentivize the use of nanofertilizers through subsidies or extension services, focusing on smallholder women farmers to maximise benefits and impact. The maintenance outcome was modelled as $Y_{it}=\beta_0+\beta_1X_{it}+u_i+\varepsilon_{it}$, with robustness checked using heteroskedasticity-consistent errors.