Urban Nigerian patients often face significant financial burdens when purchasing prescription medications, leading to unmet healthcare needs and reduced access. A mixed-methods approach including surveys and focus groups was employed to assess user engagement with e-vouchers and their effectiveness in lowering healthcare expenses. E-voucher system users reported a significant average savings of $2.50 per prescription, with over 60% indicating increased medication adherence due to reduced out-of-pocket costs. The e-voucher system was widely adopted and effectively reduced the financial barriers associated with purchasing prescription medications in urban Nigeria. Further implementation should consider tailoring e-voucher designs to align with local healthcare needs and preferences. E-Vouchers, Prescription Medications, Urban Nigeria, Savings Analysis Treatment effect was estimated with $\text{logit}(p_i)=\beta_0+\beta^\top X_i$, and uncertainty reported using confidence-interval based inference.