Modern physics has achieved remarkable success describing natural phenomena throughthe concepts of particles, fields, and spacetime geometry. However, theoreticaldevelopments over the past century increasingly suggest that these entities may notrepresent fundamental physical reality. Quantum field theory interprets particles asexcitations of fields, while several approaches to quantum gravity indicate that spacetimeitself may be emergent.The Space-Phase (SP3) framework proposes that these entities arise as manifestations of adeeper physical substrate: a conditionable medium capable of supporting gradients,structural memory, trajectory focusing, and stable containment structures. If such amedium underlies physical phenomena, the priorities of future physics research wouldshift from identifying ever smaller constituents of matter toward understanding theorganizing dynamics of the substrate itself.This paper outlines research directions that become particularly important under the SP3assumption, including cross-scale structural studies, investigation of medium memoryeffects, gradient-guided motion, nonlinear containment dynamics, and astrophysicalstructure formation. At the same time, several ongoing research programs may requireconceptual reframing if particles, fields, and spacetime are emergent rather thanfundamental entities.