Based on a review of current literature, there is growing concern that COVID-19 vaccines might, in certain cases, create a biological environment that could promote cancer progression or recurrence in oncology patients. We present here the incidence of new cancers in the past years which all show a recent significant rise, especially since the end of 2021 in the USA. Cancer incidence is known to be linked including tobacco smoke, diet imbalance and pollution. We analyze here the possibility of an impact of COVID vaccines, in particular mRNA COVID injections in cancer rising globally. This hypothesis is supported by the multiple peer-published reports of altered mechanistic pathways, all of which leading to carcinogenesis, including decrease of innate immunity (decrease of NK cells and Toll-like receptors (TLR) response) andimmune dysregulation (IgG4 increase, interferon signaling imbalance), chronic inflammation, altered ACE2 associated pathways (renin-angiotensin-aldosterone system (RAAS), the kininogen-kinin-kallikrein System (KKS)), disruption of tumor suppressor pathways, presence of residual DNA, telomeres damages and metabolic pathways disturbance (Warburg effect). Given that similar molecular disruptions may also occur during SARS-CoV-2 infection, further investigation is urgently needed to clarify the potential effects of the virus as well as COVID vaccines on cancer dynamics, in order to inform future public health strategies.