The Invariance Maintenance Condition (IMC) [Thomas, 2026a] identifies the class of systems that actively maintain structural invariants under perturbation at measurable cost. This paper demonstrates that the awake human cortex satisfies all four IMC applicability conditions and that pharmacologically induced anesthesia constitutes a controlled perturbation of the awake attractor across the IMC’s threshold structure. We provide an explicit variable-by-variable correspondence between IMC objects and clinical and neurophysiological objects, expressed in standard anesthesia terms. We derive four predictions: a precursor cost signature preceding Loss of Responsiveness (LOR); structural asymmetry between induction and emergence trajectories; a temporally ordered three-surface precursor pattern specified by the R(t) decomposition; and a destruction threshold asymmetry distinguishing reversible anesthetic suppression from irreversible cortical damage. The third prediction is the subject of an independently pre-registered empirical program (Thomas, 2026b). The anesthesia domain is distinguished from the preceding IMC translations by two features: maintenance cost is directly measurable in real-time clinical units (CMRO₂), and the threshold structure has established clinical correlates (LOR, ROR, anesthetic coma) that permit immediate empirical contact.