The mass-energy equivalence E=mc2 is a cornerstone of modern physics. When applied to the concept of teleportation understood as manifestation port switching, a fundamental question arises: if an object of mass m disappears at point A and reappears at point B, does its rest energy mc2 vanish and reappear, seemingly violating energy conservation? This paper re-examines this question within the Instantaneous Teleportation Cosmos (ITC) framework, demonstrating that teleportation is not the movement of physical particles but the switching of the projection port of a basal information cluster. Energy conservation holds in a new form within the ITC framework: the rest energy mc2 is always carried by the information cluster and never disappears; the excitation energy required for port switching is independent of mc2. This paper systematically elaborates the physical basis of this mechanism from first principles. It clarifies the rigorous meaning of the statement “excitation energy is independent of mass”, pointing out that, under identical geometric and electromagnetic conditions, changing the mass itself does not affect the coupling energy. Finally, experimentally testable predictions are provided, offering a logically self-consistent energetic foundation for the Spacetime Editing Theory.