This dataset documents the psychological, psychiatric, clinical and psychosocial assessment of individuals affected by COVID-19 in Senegal during the early phase of the pandemic in 2020. It includes 139 individual records and 103 variables related to sociodemographic characteristics, COVID-19 clinical history, psychiatric antecedents, perceived experience of illness and confinement, health behaviors, and psychological well-being indicators. The dataset is relevant for research in global mental health, psychiatric epidemiology, public health preparedness, and psychosocial responses to infectious disease outbreaks in low- and middle-income settings.