Profiler v1.2 Open-omics analysis platform, proteomics, metabolomics, lipidomics, transcriptomics and more. Published in Bioinformatics, Oxford University Press, 2026. DOI: 10.1093/bioinformatics/btaf644 What's New GSEA — Gene Set Enrichment Analysis from any analysis output (volcano, heatmap, Venn/UpSet), joining ORA across 100+ databases Regression modeling : ML and MLP for continuous targets; R², RMSE, residual plots, cross-validation Longitudinal analysis : mixed-effects models, trajectory visualisation, repeated-measures statistics (Subject_ID + Time columns) HTML report generator : one-click self-contained export of all session plots, tables, and metrics Clinical metadata support : any column ending with _meta is treated as clinical metadata; available as alternative classification/regression targets, and used to colour heatmap annotations, PCA/UMAP points, and model training New graphical interface : Redesigned UI with improved layout, cleaner navigation, and a live pipeline status indicator updated at each step Extended format support : auto-detection extended to Spectronaut, FragPipe, DESeq2/edgeR, Salmon, kallisto, MetaboAnalyst, XCMS, MZmine... Bug fixes & stability Installation Windows (recommended) Download the ZIP below Extract it Double-click install_profiler.cmd Launch from the Profiler Desktop shortcut on your Desktop Linux / macOS (manual) conda create -n profiler python=3.8.20 conda activate profiler pip install -r requirements.txt python profiler_desktop.py No administrator rights required. Full instructions in the README. Test Datasets Sample datasets for all omics types available at: https://github.com/yanisZirem/Profiler_v1_requests_datatests Links | | | |---|---| | Web platform | https://prism-profiler.univ-lille.fr | | Publication | https://doi.org/10.1093/bioinformatics/btaf644 | | Test datasets | https://github.com/yanisZirem/Profiler_v1_requests_datatests | | PRISM U1192 | https://www.inserm.fr/en/research-inserm/prism-u1192/ | PRISM INSERM U1192 — Université de Lille Developed by Yanis Zirem · Supervised by Prof. Michel Salzet & Prof. Isabelle Fournier APP/IDDN.FR2.0013.0300044.0005.S6.C7.20258.0009.312301