This article explores the major problems and distinctive features of lexical change in Global English in the context of globalization, intercultural communication, and ongoing linguistic variation. As English increasingly functions as a global lingua franca, it undergoes continuous transformation influenced by social, cultural, technological, and economic factors. The study examines key processes such as lexical innovation, borrowing from other languages, semantic shift, word formation, and hybridization, which contribute to the dynamic expansion of the English vocabulary. Special attention is given to the tension between standardization and localization, where global norms of English interact with local linguistic identities and cultural practices. The article also highlights the challenges lexical change poses for linguistic norms, language teaching, dictionary compilation, and cross-cultural understanding. Drawing on contemporary linguistic theories and empirical research, the study provides a comprehensive overview of how Global English reshapes and diversifies the English lexicon in different regions of the world.