Urbanization in Ghana has led to increased stressors such as job insecurity and social isolation, contributing to higher rates of depression among urban populations. A mixed-methods approach combining qualitative interviews with urban residents and quantitative surveys of healthcare providers to assess current policy impact. The analysis revealed a significant gap between the prevalence of depression identified through community health surveys (40%) compared to reported cases by healthcare workers (25%). Current policies are insufficient in addressing depression, particularly among marginalized urban groups. There is a need for more targeted interventions and improved data collection methods. Develop culturally-sensitive mental health resources tailored to urban contexts, integrate depression screening into primary healthcare services, and enhance collaboration between sectors.