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Project proposal . 2026
License: CC BY
Data sources: Datacite
ZENODO
Project proposal . 2026
License: CC BY
Data sources: Datacite
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Conformational correction in trans of CFTR-F508del using a prion-like template: a novel therapeutic strategy for cystic fibrosis

descriptionPublicationkeyboard_double_arrow_right Project proposal 05 Mar 2026Publisher:Zenodo
Authors: GACI, Mélia Jade;

doi: 10.5281/zenodo.18876053 , 10.5281/zenodo.18876052

Conformational correction in trans of CFTR-F508del using a prion-like template: a novel therapeutic strategy for cystic fibrosis

Abstract

Doctoral research proposal submitted as part of a PhD application. This proposal was developed during a visiting exchange year at the University of St Andrews (Scotland, UK) by a student enrolled at Sorbonne Université (Paris, France). It outlines an original hypothesis for the therapeutic correction of CFTR-F508del misfolding in cystic fibrosis, based on the repurposing of the prion conformational conversion mechanism as a trans-acting folding template.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
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