Wound management remains a persistent clinical challenge, particularly in the context of chronic ulcers, diabetic wounds, surgical site infections, and antibiotic resistance. Ayurveda, the traditional system of medicine of India, offers a comprehensive and structured approach to wound care through the dual principles of Vrana Shodhana (wound purification) and Vrana Ropana (tissue regeneration). Classical Ayurvedic texts, especially the Sushruta Samhita, describe detailed classifications, pathogenesis, and stage-wise management of wounds that remarkably parallel modern concepts of wound bed preparation and phased tissue repair. This review explores the similarities between Ayurvedic wound care and modern medical science. It highlights how Ayurvedic principles can serve as a supportive and evidence-based approach, especially in chronic and difficult-to-heal wounds. Further research, better standardization, and clinical studies are needed to safely integrate classical Ayurvedic knowledge into modern wound care practice, which may help improve patient outcomes and broaden available treatment options. By bridging ancient wisdom and modern science, the article highlights potential synergies, gaps in research, and future directions for integrative wound care.