Heart failure remains one of the leading causes of hospitalization and mortality worldwide, while the impact of seasonal weather factors on the course of the disease has not been fully elucidated. The aim of this study is to assess the effect of seasonal weather conditions on the frequency of hospitalizations among patients with heart failure. The study used data on inpatient hospitalizations for heart failure over a long-term period, as well as meteorological indicators including air temperature, humidity, atmospheric pressure, and seasonal variability of weather conditions. The analysis was conducted using time-series methods and correlation analysis to identify associations between weather factors and hospitalization rates. The results demonstrated pronounced seasonal variability in heart failure–related hospitalizations, with an increase during colder periods of the year and a decrease in warmer seasons. Low temperatures and abrupt weather fluctuations were associated with a higher risk of heart failure decompensation and the need for inpatient treatment. The findings confirm the significant role of seasonal weather factors in shaping the risk of hospitalizations due to heart failure. Consideration of climatic and seasonal characteristics may contribute to improved preventive strategies, optimization of medical monitoring, and reduction of the burden on the healthcare system.