Chronic obstructive pulmonary disease (COPD) is one of the global health problems and is considered one of the leading causes of death and disability. Patients with COPD frequently experience cardiovascular diseases, which significantly worsen the prognosis of the disease. This article analyzes the pathogenetic relationship between COPD and cardiovascular diseases, the clinical course characteristics, mechanisms of complication development, and their impact on treatment effectiveness based on scientific sources. The role of environmental and demographic factors in the Fergana region is also highlighted.