In recent years, ethosomes have been employed extensively as a transdermal drug delivery system due to their improved bioavailability, modified release characteristics, and compatibility as compared to topical formulations that are currently accessible. Because of their enhanced bioavailability, altered release properties, and compatibility with currently available topical formulations, ethosomes have been widely used as a transdermal drug delivery system in recent years.In this study, the cold technique was used to prepare fluconazole-entrapped ethosomes for topical administration.Size, percentage entrapment, pH, viscosity, in vitro drug release study, and interaction study were assessed for the prepared ethosome formulation.The optimal formulation was selected based on its size, entrapment effectiveness, and release profile. The findings of measuring the viscosity and pH of the fluconazole ethosomes trapped in gel were satisfactory, confirming that ethosomes could be an effective carrier for fluconazole topical delivery.