The emergence of the global opioid crisis as a severe public health emergency has greatly affected morbidity, mortality, and healthcare systems linked with it. Just as alarming are the overdose death rates being reported in the USA-72,000 in 2021 alone. (Woldemariam Y. et al, 2021) Nevertheless, the opioid misuse is on the rise in Europe, Asia, and parts of Africa. Urban misuse of heroin, tramadol, and prescription opioids is rising in India and sub-Saharan Africa because of weak regulatory frameworks and poor oversight of pharmacies. As in most countries, pharmacists are accessible healthcare providers carrying the major responsibility in combating the problem of opioid misuse via patient education, monitoring prescriptions, and harm-reducing interventions. (Choi NG. et al, 2024) This narrative review analyses global research undertaken between 2000 and 2025 to assess the role of community pharmacists in prescribing and dispensing of opioids, emphasize regulatory compliance, patient safety, and inter-professional collaboration. Evidence highlights common barriers across countries including lack of training, poor enforcement, pressure from corporate entities, and limited privacy offered to patient counseling. This review suggests integrated policy reform, providing an avenue for the empowerment of pharmacists through education and clarity in law, and expansion of pharmacist-led interventions, such as naloxone, digital screening tools, and opioid safety education. (Bratberg JP., 2017) Ultimately, coordinated global efforts are essential in enhancing the ability of community pharmacists to tackle the multifaceted opioid epidemic and promote safer use of controlled substances.