The imidazole topical ketoconazole has long been used to treat fungus diseases and seborrheic dermatitis. Ketoconazole inhibits fungus ergosterol production, a component of cell membranes, and has other antifungal properties. Ketoconazole is also available as a cream, solution, and shampoo to treat skin fungus diseases. common side effects include itching, nausea, rash, stomach pain, headache, vertigo, tiredness, impotence, menstruation irregularities, and gynecomastia. Ketoconazole foam and gel versions for the therapy of seborrheic dermatitis have recently been introduced to the market, and they are successful against superficial fungal and yeast diseases. In 1981, the FDA authorised ketoconazole as the first broad-spectrum dietary antifungal. Post-marketing complaints of hepatotoxicity, adrenocortical insufficiency, endocrine dysregulation, and medication interactions led in the medicine being withdrawn from the market in some countries and severe product relabelling in others. Keywords: Oral Ketoconazole, Adverse effect of oral ketoconazole (hepatotoxicity, Adrenocortical Insufficiency, endocrine dysregulation), Contraindications of oral ketoconazole,