Background: Nutrivigilance is a discipline focused on the detection, assessment, and prevention of adverse effects associated with dietary supplements and nutraceuticals. In spite of increasing consumption of these products, awareness, reporting practices among healthcare professionals is suboptimal. Aim: To assess the knowledge, attitude, and practices (KAP) regarding nutrivigilance among postgraduate students and clinicians in a tertiary care teaching hospital. Methods: A hospital-based cross-sectional observational study was done among 500 postgraduate students and clinicians using a pre-validated, structured questionnaire. The questionnaire assessed sociodemographic details and KAP domains. Results: Among 500 participants, 50.6% showed moderate knowledge. 25.4% had good knowledge and 24.0% had poor knowledge regarding nutrivigilance. Awareness of nutrivigilance was reported by 63.4%. 52.8% were aware of existing reporting systems. A positive attitude towards nutrivigilance was seen in 65.4% of participants. 74.6% had prescribed nutraceuticals and 33.6% had encountered adverse events, but only 13.2% reported these events. 56.8% showed poor practice levels. Conclusion: In spite of positive attitude, there is significant gap in the knowledge and reporting practices related to nutrivigilance. Structured educational interventions and strengthened reporting mechanisms are needed to enhance safety surveillance of nutraceuticals and promote patient safety