This deliverable D6.1 describes the validation of trustworthiness of disaggregated and energy efficient computing architectures and summarizes the impact of behaviour and performance of components and architecture for the delivery of end-to-end-trusted services. It demonstrates the results from WP4 (Digital Components) and WP5 (Analog Components) based on simulation and experimentation over different realistic scenarios and validates the results against use case requirements from WP2 and trustworthy disaggregated computing architectures defined in WP3. At least one validation is performed for each of the four combinations: trustworthy radio links (WP5 trustworthiness), M³ computation platforms (WP4 trustworthiness), accelerated signal processing capabilities based on a RISC-V platform (WP4 efficiency), high data-rate interconnects using sub-THz plastic waveguides (WP5 efficiency).