Synonymous ADHFE1 Variation Shapes Population Tolerability of the Deleterious ALDH2 rs671 Allele
Takuya, Seike; Che-Hong, Chen; Renata, Rosseto; Abir, Mondel; Suman, Pokhrel; Tony Pan- Hou, Che; Yi-Cheng, Chang; +1 Authors
Takuya, Seike; Che-Hong, Chen; Renata, Rosseto; Abir, Mondel; Suman, Pokhrel; Tony Pan- Hou, Che; Yi-Cheng, Chang; Daria, Mochly-Rosen;
Synonymous ADHFE1 Variation Shapes Population Tolerability of the Deleterious ALDH2 rs671 Allele
This study identifies population-specific common and rare genetic variants by analyzing allele frequency differences across populations using gnomAD v2.1.1 exome sequencing data. We developed a customized filtering pipeline that performs rigorous quality control and stratified analysis across seven genetic ancestries: East Asian (EAS), South Asian (SAS), Non-Finnish European (NFE), Finnish (FIN), African (AFR), Admixed American (AMR), and Ashkenazi Jewish (ASJ).
ADHFE2, Synonymous mutation, mRNA stability, ALDH2
ADHFE2, Synonymous mutation, mRNA stability, ALDH2
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selected citations
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These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
Citations provided by BIP!popularityPopularity provided by BIP!
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
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