Current interventions for advanced atherosclerosis rely on brute-force mechanical disrup-tion of calcified plaques, presenting significant risks of macroscopic emboli and downstreamischemia. We propose a non-surgical clearance modality utilizing targeted, biomimeticacoustic nanocarriers to induce localized brittle failure of arterial calcification. By exploit-ing the profound acoustic impedance mismatch between rigid hydroxyapatite lattices andthe highly compliant extracellular matrix, an attenuated, high-frequency acoustic standingwave (1 MHz – 4 MHz) can selectively pulverize the calcified lattice layer-by-layer. Deliveredvia lipid-polymeric micro-emitters engineered with strict spatial, electrostatic, and temporalconstraints, this method offers a mathematically self-regulating pathway for restoring arte-rial elasticity without generating macroscopic debris or risking systemic bioaccumulation.