Abstract The present study examined the relationship between spirituality and psychological distress, specifically depression, anxiety, and stress, and explored differences in coping styles between individuals in young and middle adulthood. Using a comparative and correlational research design, data were collected from 106 adults, including 56 young adults and 50 middle adults. Spirituality was assessed using the Spiritual Health Assessment Scale, psychological distress was measured using the Depression Anxiety Stress Scale 21, and coping strategies were evaluated using the Brief Coping Orientation to Problems Experienced Scale. Pearson product moment correlation analysis was employed to examine associations between spirituality and psychological distress, while two-way analysis of variance was used to compare coping styles across age groups. The results indicated that spirituality was not significantly associated with depression, anxiety, or stress. However, strong and statistically significant positive relationships were observed among depression, anxiety, and stress. Further analysis revealed no significant differences in coping styles between young and middle adults, and the effect of age group on coping was negligible. These findings suggest that spirituality may not function as a direct protective factor against psychological distress in non-clinical adult populations and that coping styles may remain relatively stable across young and middle adulthood. The study highlights the complexity of the relationships among spirituality, coping, and mental health and underscores the need for further research examining specific dimensions of spirituality and their interaction with coping processes across developmental stages. Keywords: Spirituality; Depression; Anxiety; Stress; Coping styles.