This dataset contains stratigraphic, geophysical, and kinematic parameters used to constrain the evolution of Plio–Pleistocene fault systems. It includes (1) stratigraphic ages and associated uncertainties based on published chronostratigraphic frameworks, (2) interval velocity models applied to the main stratigraphic units, (3) calculated fault slip and slip rates derived from restored cross-sections with related uncertainties, and (4) parameters of statistically fitted slip-rate curves with goodness-of-fit metrics and time-derivative estimates. The dataset supports quantitative reconstruction of fault activity and temporal variations in slip rates through integrated stratigraphic constraints and velocity modeling. This dataset supports the manuscript: De Matteo A. , F. Maesano, D. Barrera, R. Basili, S. Seno, M. Livani, D. Scrocca, Vanja Kastelic and G. Toscani, Probabilistic assessment of variable slip rates of offshore buried thrusts in the Central Adriatic Sea (Italy) since the Pliocene time, Under review in Tectonics.