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Article . 2026
License: CC BY
Data sources: Datacite
ZENODO
Article . 2026
License: CC BY
Data sources: Datacite
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DUAL-MODE, RATE-AWARE SWEAT SENSING WITH UNCERTAINTY-INFORMED ANALYTICS FOR HYPERHIDROSIS SCREENING AND MONITORING

Authors: PADMA BELLAPUKONDA, DR. RAGHVENDRA KUMAR, DR. R N V JAGAN MOHAN;

DUAL-MODE, RATE-AWARE SWEAT SENSING WITH UNCERTAINTY-INFORMED ANALYTICS FOR HYPERHIDROSIS SCREENING AND MONITORING

Abstract

Wearable sweat sensing enables non-invasive screening and monitoring, but concentration-only readouts are confounded by secretion dynamics such as instantaneous rate and accumulated volume and by evaporation. These limitations are especially problematic in clinically important low-sweat regimes, including mild or treatment-modulated states, observed in hyperhidrosis. We present a dual-mode, rate-aware platform that fuses resistive wetting and contact conductance with a capacitive absorbent-dielectric channel to infer local sweat volume and rate, supported by a skin-interfaced microfluidic layer for chrono-sampling and evaporation compensation. On this hardware, we introduce RAISE, Rate-Aware Inference with Sensor Ensembles, an uncertainty-informed pipeline that derives rate-normalized features, applies probability calibration using slope and intercept with expected calibration error and Brier score, and quantifies clinical utility with decision-curve analysis, while reporting uncertainty using bootstrap confidence intervals. Using patient-level splits and an external temporally held-out validation cohort, our approach improved discrimination and reliability over a concentration-only baseline, with delta AUC of 0.06 and external AUC of 0.92 with 95 percent confidence interval from 0.88 to 0.95. It reduced expected calibration error to 0.031 and Brier score to 0.121, and yielded higher net benefit across clinically relevant thresholds, with maximum delta of 0.06 and up to 7 avoided interventions per 100 at probability threshold 0.10. Sensor characterization achieved mean absolute percentage error below 10 percent versus gravimetry with R squared up to 0.992 across four infusion rates. By coupling dual-mode sensing with rate-aware calibration and decision-focused analytics, the system delivers clear, clinically interpretable gains for dependable hyperhidrosis screening and monitoring.

Keywords

Sweat Sensing; Hyperhidrosis; Microfluidics; Dual-Mode Capacitive–Resistive Sensors; Probability Calibration; Decision-Curve Analysis.

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
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