The seven Millennium Prize Problems, announced by the Clay Mathematics Institute in 2000, represent the most profound unsolved questions in mathematics. This paper presents a unified topological and dynamical model within the Möbius-8 framework to resolve each problem through the Law of Niño (δ(t+T) = δ(t) e^{λT}), a bounded exponential asymmetry growth law calibrated with λ ≈ 0.0192 from empirical data. Using proactive back-reasoning (backward Niño: δ(t) = δ(t+T) × e^{-λT}), parallel grooves in the honeycomb matrix, and high-precision simulations, we demonstrate resolutions or extensions for all seven problems. While not formal mathematical proofs, these model-based solutions provide verifiable, falsifiable pathways with high data fits (r > 0.98) to recent advances. The Law of Niño emerges as a universal meta-law, turning asymmetry into the key to mathematical resolution.