This article analyzes trade and economic relations between Uzbekistan and the United States, focusing on their current state, existing opportunities, and key challenges. The research is conducted in the context of economic reforms in Uzbekistan and the country’s integration into the global economy. The findings show that although bilateral trade volumes remain relatively low, there is significant potential for expansion in textiles, agriculture, and services. At the same time, logistical difficulties, regulatory barriers, and market access issues continue to limit trade growth. The article offers recommendations to enhance bilateral trade cooperation.