Evaluation of Typhoid and Malaria Cases as Co-Infections among Students of College of Health Sciences and Technology, Ijero-Ekiti, Ekiti State, Nigeria Author’s Details: Kola Bamidele Jayeoba1, Blessing Alagbada2 and Mary Ania Ogbonna31Department of Basic Medical Sciences of Ekiti State College of Technology, Ijero-EkitiJayeobakola013@yahoo.com 080670953852Department of Community Health of Ekiti state College of Technology, Ijero-Ekitialagbadablessing@gmail.com080644618593Department of Health Information Management of Ekiti state College of Technology, Ijero-EkitiMartogbonna056@gmail.com07030568905 AbstractCertain mosquito species can transmit the deadly disease malaria to humans. Salmonella enterica serovar Typhi is the bacteria that cause typhoid fever, an acute systemic illness. Tropical nations are home to the majority of them. They are mostly found in tropical countries. The aim of the study is to determine the coexisting prevalence of typhoid fever and malaria fever infection among students of the College of Health Sciences and Technology, Ijero-Ekiti. . Retrospective study of research design was adopted for this study. All patients attending college of health sciences and technology Ijero-Ekiti health center. Data were collected were meticulously extracted from the hospital’s laboratory records from health center of College of Health Sciences and Technology Ijero-Ekiti after permission had been taking from management of health center. SPSS 21.0 was used to analysis the data. The data would be expressed in frequency distribution, percentage and student t-test. Findings of the study were: that 6(14.0%) of the patients were positive for widai test for typhoid fever and 37 (86.0%) were negative.. Age group of the patients tested for typhoid fever: 17-23 years had 44.2%, 22-28 years had 44.2% and 27-31 years had 11.6%. Gender of the patients tested for typhoid fever: male had 20.9% and female had 79.1%.. The infected male with typhoid fever parasite was (2.32%) while uninfected male were 8 (18.60%). Infected female were 5 (11.63%) while uninfected female were 29 (67.44%). Age group of the people undergo malaria test: 17-21 years had 49 (50.0%), 22-28 years had 39 (39.8%) and 27-31`years had 10.2%. Gender of patients did malaria test: male had 12(12.2%) and female had 87.8%. 52 (53.1%) of suspected malaria parasite were positive while 46 (46.9%) were negative. And P. value (0.i05) > Apha value (0.05). This implies that there was no significant different between malaria test results and Wida test results for typhoid fever; therefore, the hypothesis is not rejected. We concluded that the prevalence of typhoid fever is 14.0%, prevalence of malaria fever is 53.15%. And there are no difference between prevalence of typhoid fever and malaria fever. We recommended that people should go for malaria test and typhoid fever test simultaneously because of co- existing infections Key Words: Infection, Fever, life-threatening, morbidity and mortality