
this is the data and code depository for the paper "Generalization of fear learning is shaped by inhibitory sensory processing in mice", NCOMMS-25-57165. miasma.zip ; contains custom-written imaging analysis software used in this article.miasma_documentation.docx ; detailed description of files and analysis steps for miasma.xls.zip ; contains the numerical data used in the findings. rstats.zip ; contains the stats codes written in rstudio. description of files in xls: - habituation.xls: dataset for habituation/dishabituation experiment. - mobility.xls: dataset for mobility and mean calcium increase after drug application, in imaging experiments.- all the animals are listed with their groups and mobility scores for each odor.- sheet O includes OSN animals, sheet G for PG cells, sheet M for mitral. "PRD" isolates paired animals. ALL and ALL_SHORT has all the animals, latter in short format. - openfield.xls: dataset for openfield experiments.- detection: accuracy of ethovision, mobility: active time of the animals. center-zone2: percentage of time animals spent in each zone.- dists: mean distance from each zone, all danger: areas adjacent to CS+., all safe: areas adjacent to no odor.- sheet "testing_rep" includes interactable representative graphs for each point made in the paper along with additional ones.- sheet "test_dist" isolated data of distances used to run stats. - percentages.xls: dataset for calcium findings, change in df/f ater drug application.- experimental specifics of all animals listed from B to E.- odor: presented odor, roi: ROI number, max: change in df/f of peak fluorescence, maxtime: time of peak, time1-5: peak within time section, offvol/area: offset metrics.- sheets are named according to cell type of animal. _rep includes interactable graphs for findings presented. - peaks.xls: same as percentage, but divided by peaks rather than just percentages.- block: 1, before application; 2, after application. - spatial: dataset for spatial analysis.- max_pre: peak before drug, max_post: peak after drug, perc: change in df/f - roi_x/y: centroid location of the ROI, ref_x/y: centroid location of the max responding CS+ glomerulus of specific animal.- eucl: euclidian distance between the ROI and peak CS+ ROI, micron: pixel converted to microns based on lens used.- overlap: 1 if this ROI is overlapping with any other, top50: 1 if this roi is a top 50 responding ROI.- m400: 1 if ROI is within 400 microns of peak CS+ ROI. description of files in rstats: *all files include a comment for which excel file to run and what to change in order to get the specific subsection of the analysis. - calcium_mobility_correlation: Fig 2K.- compare_percentages: Fig 2 D-J.- mobility_across_odors: Fig 1C.- mobility_sex: Fig 1C, sex differences.- no_ceiling: Fig S2.- openf_distances: Fig 1D, Fig 4G-H.- overlap_glom: Fig 3C-D.- proximity_CS+: Fig 3E.- habituation: Fig 5C-D.
Learning and Memory, Systems Neuroscience, Olfaction
Learning and Memory, Systems Neuroscience, Olfaction
| selected citations These citations are derived from selected sources. This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | 0 | |
| popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network. | Average | |
| influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Average | |
| impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Average |
