Powered by OpenAIRE graph
Found an issue? Give us feedback
ZENODOarrow_drop_down
ZENODO
Article . 2026
License: CC BY
Data sources: Datacite
ZENODO
Article . 2026
License: CC BY
Data sources: Datacite
ZENODO
Article . 2026
License: CC BY
Data sources: Datacite
ZENODO
Article . 2026
License: CC BY
Data sources: Datacite
versions View all 4 versions
addClaim

SNEDDS – A Novel Technology Approach for Nano Emulsion Based Drug Delivery of Curcumin

Authors: Bhagyesh Janugade*, Samruddhi Desai, Pratiksha Desai, Harsha Bhosale, Gayatri Atpadkar;

SNEDDS – A Novel Technology Approach for Nano Emulsion Based Drug Delivery of Curcumin

Abstract

A promising method for improving the solubility and bioavailability of all poorly soluble drugs is SNEDDS (Self Nano-emulsifying drug delivery system). SNEDDS are an isotropic combination of oil, co-surfactant, and surfactant that forms oil in water on its own. nano-emulsion in gastric fluid after slight stirring. The nanosized droplets significantly boost the solubilization, surface area and absorption of lipophilic medicines like curcumin. Curcumin is a natural polyphenolic chemical derived from Curcuma longa, with multiple medicinal effects including anti-inflammatory, antioxidant, antirheumatic, antibacterial action. But it falls under BCS class IV shows both low solubility and poor absorption. However, because of its weak aqueous solubility, low permeability, and fast metabolism, which results in low oral bioavailability, its therapeutic applicability is restricted. The current study focuses on creating and assessing curcumin-loaded SNEDDS to improve solubility and bioavailability in order to address these problems. The Nano carrier technology of SNEDDS boost curcumin loaded capability to be transported and absorbed into diverse organ by improving its ability to cross cell membrane. Different approaches can be used to generate SNEDDS. SNEDDS is an effective method for optimizing the oral delivery of drugs with low water solubility, increasing their bioavailability in the body. The goal of the article is to examine and explore the application of SNEDDS in enriching the solubility as well as bioavailability.

Keywords

SNEDDS, Nanocarrier system, Oral drug delivery, Nano emulsion, BCS Class

  • BIP!
    Impact byBIP!
    selected citations
    These citations are derived from selected sources.
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    0
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    Average
Powered by OpenAIRE graph
Found an issue? Give us feedback
selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
0
Average
Average
Average
Upload OA version
Are you the author of this publication? Upload your Open Access version to Zenodo!
It’s fast and easy, just two clicks!