
A promising method for improving the solubility and bioavailability of all poorly soluble drugs is SNEDDS (Self Nano-emulsifying drug delivery system). SNEDDS are an isotropic combination of oil, co-surfactant, and surfactant that forms oil in water on its own. nano-emulsion in gastric fluid after slight stirring. The nanosized droplets significantly boost the solubilization, surface area and absorption of lipophilic medicines like curcumin. Curcumin is a natural polyphenolic chemical derived from Curcuma longa, with multiple medicinal effects including anti-inflammatory, antioxidant, antirheumatic, antibacterial action. But it falls under BCS class IV shows both low solubility and poor absorption. However, because of its weak aqueous solubility, low permeability, and fast metabolism, which results in low oral bioavailability, its therapeutic applicability is restricted. The current study focuses on creating and assessing curcumin-loaded SNEDDS to improve solubility and bioavailability in order to address these problems. The Nano carrier technology of SNEDDS boost curcumin loaded capability to be transported and absorbed into diverse organ by improving its ability to cross cell membrane. Different approaches can be used to generate SNEDDS. SNEDDS is an effective method for optimizing the oral delivery of drugs with low water solubility, increasing their bioavailability in the body. The goal of the article is to examine and explore the application of SNEDDS in enriching the solubility as well as bioavailability.
SNEDDS, Nanocarrier system, Oral drug delivery, Nano emulsion, BCS Class
SNEDDS, Nanocarrier system, Oral drug delivery, Nano emulsion, BCS Class
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