Dental implants are widely used to restore missing teeth, providing both functional and aesthetic benefits. However, their long-term success is influenced not only by local factors such as bone quality and surgical technique but also by systemic health conditions. Chronic systemic inflammation, arising from diseases like diabetes mellitus, autoimmune disorders, and cardiovascular conditions, can impair bone healing, delay osseointegration, and increase the risk of peri-implant complications. This paper reviews the mechanisms by which systemic inflammation affects implant stability, including the role of pro-inflammatory cytokines, altered bone metabolism, and impaired soft tissue regeneration. Clinical assessment and management strategies are discussed to optimize treatment outcomes. Understanding the impact of systemic inflammation on dental implant success allows clinicians to implement individualized treatment plans, reduce complications, and improve long-term functionality and aesthetics.