Fagonia cretica Linn. is known for its medicinal properties in traditional Ayurveda practices. This plant, commonly called Dhamas in Hindi, belongs to the Zygophyllaceae family. Dhanvayasa has been traditionally used to treat various ailments and improve overall health naturally. Fagonia cretica Linn. is a source drug for the plant Dhanvayasa. Vatarakta is one such disease where the kashaya of Dhanvayasa Panchanga is used. A contemporary scientific correlation for vatarakta is gout, which is characterized by Hyperuricemia. Dhanvayasa (Fagonia cretica Linn.) drug will be collected from authorized raw drug suppliers, Purnaksha Ceuticals, Nashik (Maharashtra). The macro-microscopic features, Physico-chemical test and Preliminary phytochemical tests done as per authentic text book. The anti-hyperuricemic activity has been assessed by Potassium oxonate induced hyperuricemic model. The experimental research indicates that the whole plant demonstrates significant effectiveness in anti hyperuricemic activity. The study has indicated that Dhanvayasa kashaya possesses potential activity against hyperuricemia.