The increasing prevalence of Skin diseases due to unhealthy eating practice of current situation, hence there is need to explore drugs which can be used in daily diet to prevent possible skin diseases or it can be used as a diet in patient suffering from skin disease. Hence, exploring on the Shaka Varga of Bhavaprakasha Nighantu, focusing mainly on 12 Kushtaghna Dravyas out of total 71 drugs. These 12 drugs are critically analyzed through their Rasapanchaka and how potentially these drugs are useful in prevention and treatment of Skin diseases.