Fibromyalgia (FM) is a chronic pain disorder characterized by widespread musculoskeletal pain, fatigue, and psychological distress, often coexisting with migraine, irritable bowel syndrome, and depression, suggesting shared pathophysiology involving genetic factors like polymorphisms in COMT and serotonin transporter genes. In Ayurveda, FM correlates with Vata Vyadhi, particularly vitiation of Mamsavaha, Asthivaha, and Majjavaha Srotas. This case study evaluated a FM patient using modern diagnostic criteria, interpreting it as Mamsagata Vata. Treatment comprised Vata-shamana and Balya therapies, including internal medications, Abhyanga, and Basti Karma. The patient exhibited significant improvements in pain, stiffness, fatigue, sleep quality, and functional activity. These findings indicate that Ayurvedic management rooted in Vata Vyadhi principles, emphasizing Mamsagata Vata, effectively alleviates FM symptoms, offering a holistic integrative approach.