Abstract: Reproductive function is known to be disrupted by inflammation, and Zingiberofficinale, has long been used to treat inflammatory diseases. In this work, male albino Wistarrats with albumin-induced inflammation were used to assess the modulatory effects of Zingiberofficinale ethanol extract on reproductive hormones, such as testosterone, follicle-stimulatinghormone (FSH), and luteinizing hormone (LH). A control group, an inflammation-inducedgroup, and groups treated with different dosages of Zingiber officinale ethanol extractcomprised the five (5) groups of thirty (30) male albino Wistar rats. Albumin was used to causeinflammation, and the extract was taken orally for three weeks. Standard laboratory methods,such as enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay (RIA), were usedto evaluate hormone levels. The results showed that Zingiber officinale ethanol extractsignificantly modulated reproductive hormone levels in the treated groups compared to thecontrol groups. Specifically, testosterone levels increased (14.39 ± 0.0003), while FSH and LHlevels showed dose-dependent responses. The findings suggest that Zingiber officinale ethanolextract may have a regulatory effect on reproductive hormone production in male albino Wistarrats with albumin-induced inflammation, potentially due to its anti-inflammatory andantioxidant properties. These results have potential implications for the treatment ofreproductive disorders associated with inflammation and warrant further investigation into themechanisms underlying the modulatory effects of Zingiber officinale on reproductivehormones.