The aim of this research is to prepare Methotrexate transdermal patches were formulated using HPMC and PVP as film forming polymers. patches were prepared by solvent casting method and evaluated for physicochemical properties. In order to obtain best optimised products. 9 different formulations were developed different polymers like HPMC, PVP, ethanol, glycerine dissolving in minimal amount of acceptable solvent. the prepared patches evaluate to physical appearance, determination of drug content, in vitro drug release. formulation F9 contain HPMC and PVP (500) shows maximum drug release, produced flexible, smooth films with good mechanical properties. compared to other formulations.