This study examines the quality of work life among female school teachers in Thiruvananthapuram district in Kerala. The study investigates; various organizational and personal factors influence their professional well-being and satisfaction. The comprehensive literature review, identifies gender inequality, workplace stress, work-life balance challenges, and organizational support as critical dimensions The research employs quantitative methodology to assess the key variables, like workload, working hours, flexibility, organizational support, and stress levels among fifty participants. Descriptive statistical analysis reveals that organizational support emerges as the most consistently positive factor with the highest mean and lowest variability. On the other hand, workload presents the lowest satisfaction levels with significant individual differences in stress experiences. Correlation analysis indicates a significant negative relationship between organizational support and stress levels, that reflects an enhanced organizational support, that effectively mitigates workplace stress among female teachers. The findings suggest that targeted interventions focusing on workload management, improved work flexibility, sustained organizational support, and stress reduction strategies are essential for enhancing the quality of work life and professional sustainability of female school teachers in Thiruvananthapuram.