Ashta Ghrita represents a systematic and clinically oriented classification of Ghrita in Ayurveda, wherein ghee obtained from different animal sources is differentiated based on its specific therapeutic properties. The concept of Ashta Ghrita as described in Laghutrayee reflects the advanced understanding of ancient scholars regarding the influence of the source of milk on the Rasa, Guna, Virya, Vipaka and Dosha-Karma of Ghrita. Instead of considering ghee as a single uniform substance, Laghutrayee recognizes multiple forms of Ghrita with distinct physiological actions and disease-specific applications. These variations enable precise selection of Ghrita according to Dosha predominance, Agni status, tissue involvement and chronicity of disease. According to Laghutrayee, Ghrita is described as Snigdha, Guru, Sheeta and Madhura, with predominant Vata-Pitta Shamaka action and strong Rasayana, Balya and Medhya properties. The individual types of Ashta Ghrita are indicated in diverse clinical conditions such as digestive disorders, respiratory diseases, neurological conditions, gynecological disorders and states of Dhatukshaya. A unique emphasis is placed on the role of Ghrita as a Yogavahi, capable of carrying the properties of processed drugs deep into tissues through Sanskaranuvartana. Thus, the general introduction of Ashta Ghrita in Laghutrayee highlights a highly individualized, rational and disease-specific approach to therapy. This review underscores the importance of understanding classical distinctions among different types of Ghrita to enhance clinical decision-making and preserve the foundational principles of Ayurvedic therapeutics.