Introduction: In Ayurveda all kinds of skin diseases are mentioned under the heading of Kushta. Charmadala is one among Kshudra kushtas by most of the Acharyas. Kashyapokta Charmadala is a Vata Pradana Tvak Vikara and it is commonly seen in children as they are Sukumara and have Asthira dhatus. Based on its symptoms, Charmadala can be correlated with Atopic dermatitis (AD). The prevalence of AD has increased in recent years, yet conventional treatments, such as topical steroids, often lead to skin sensitivity. Therefore, there is a need for alternative treatments. This study aims to evaluate the effectiveness of Pugadi Ksheera Seka and Panchatikta Ghrita Lepa in treating Vataja Charmadala, which is clinically comparable to Atopic dermatitis in children. Methods: In this study, 40 subjects diagnosed with Vataja Charmadala were randomly selected and assigned in to two groups, with 20 subjects in each groups. Group A (trial group) was administered with Pugadi Ksheeraseka and Group B (control group) was given with Panchatiktaghrita Lepa. Intervention was given for 7 days and study period was of 21 days. Assessment was done on 0th day, 7th day, 14th day and 21st day based on Ayurvedic parameters and SCORAD index of Atopic dermatitis. The data obtained was statistically analysed by using Paired and Unpaired t –test and the results were represented in the forms of tables and graphs. Results: Both treatments showed a statistically significant reduction in symptoms of Vataja Charmadala (AD) within each group. However, between the two groups, Panchatikta Ghrita Lepa demonstrated better results. This may be attributed to the lipophilic nature of Panchatikta Ghrita, which enhances physical occlusion and improves the absorption of active ingredients into the skin. Pugadi Ksheera Seka, which contains Vatahara drugs in a liquid medium, also contributed to symptom reduction, though it was less effective compared to the Ghrita-based formulation. Interpretation and Conclusion: Pugadi Ksheera Seka, containing Vatahara herbs in a liquid medium, helped in reducing Vata and alleviating the symptoms of Vataja Charmadala. Panchatikta Ghrita, known for its Kushtaghna properties and lipid base, was more effective due to its superior ability to occlude the skin and enhance absorption of active compounds. Both treatments were effective in managing Vataja Charmadala, but Panchatikta Ghrita Lepa showed better results overall. Thus, both therapies can be considered viable options for treating atopic dermatitis in children, with Panchatikta Ghrita Lepa being more efficacious.