Abstract: In this study, lipid peroxidation in terms of TBARS formed and antioxidant defence comprising both antioxidant enzymes and non-enzymatic antioxidants were assessed in the liver tissue of common Asian toads during hibernation and compared with the summer active toads. A significant (P<0.001) increase in lipid peroxidation was found in liver tissue during hibernation. Concomitantly significant (P<0.001) increase in catalase activities was also found during hibernation, with an elevated superoxide dismutase activity both during hibernation and the summer active period. Ascorbic acid, a potent non-enzymatic antioxidant, was also found to be augmented during hibernation compared to summer-active toads. However, reduced glutathione (GSH) was found at low levels during hibernation compared to the summer active period. It may be due to its low rate of biosynthesis during the hypo metabolic condition of hibernation. Increased lipid peroxidation, an indication of oxidative stress and augmented antioxidant defence that were found in this investigation, are not only an adaptive response during hibernation but also a preparation for the oxidative burst expected during arousal from hibernation. Keywords: Hibernation, oxidative stress, Lipid peroxidation, antioxidant enzymes, and non-enzymatic antioxidants. Title: LIPID PEROXIDATION AND ANTIOXIDANT DEFENCE IN LIVER TISSUE OF HIBERNATING COMMON ASIAN TOADS, Duttaphrynus melanostictus Author: Sibakalyani Acharya, Debadas Sahoo, Nidhi Goyal International Journal of Life Sciences Research ISSN 2348-313X (Print), ISSN 2348-3148 (online) Vol. 14, Issue 1, January 2026 - March 2026 Page No: 16-26 Research Publish Journals Website: www.researchpublish.com Published Date: 26-February-2026 DOI: https://doi.org/10.5281/zenodo.18788779 Paper Download Link (Source) https://www.researchpublish.com/papers/lipid-peroxidation-and-antioxidant-defence-in-liver-tissue-of-hibernating-common-asian-toads-duttaphrynus-melanostictus